RAPAMYCIN MISHAP- Is your dog safe?

IM004005 snoofy smile

This is a brief entry to let others know that rapamycin may not be safe for dogs. It is certainly too early to know if the rapamycin helped or harmed my dog, but I have some information which makes me glad I restricted this trial to one dog.

I chose to medicate an older dog who was facing pain and mobility issues which may have led to my decision to euthanize him. He suffered from food allergies and allergic dermatitis, so I was able to procure an Rx for an immune-suppressant, rapamycin. I was interested in treating these issues, but even more interested in a potential rejuvenation that may save his mobility and his life. I had nothing to lose in trying a novel approach to treat his arthritis.

Aside from hypothyroidism and food allergies, he was physiologically healthy. His Arthritis was in joints which were damage due to a puppyhood trauma. He had a multiply-fractured femur which was not surgically repaired and and had become grossly deformed causing alignment issues in the hip and knee. I rescued him as an adult, so I had no part in the neglect which resulted in the deformed leg, however given the severity of the break and the location of one complete fracture at each growth plate, this deformity may have been innevitable. A vet had suggested amputation when he was 1 year old, but I instead tried an anti-inflammatory diet and exercise to strengthen the joints. He’s been using that leg for 14 years, so I am glad I didn’t amputate it. That said, the leg is now painful and amputation isn’t likely an option in a 15 year old dog…. who now has kidney disease.

That’s the point I was getting to. After trialing Rapamycin on an intermittent dosing schedule for 3 months, I noticed increased thirst in my test subject. Bloodwork revealed kidney disease. We can’t establish causation at this point, but rapamycin has been implicated in renal disease in some studies (1,2). However, in other studies, it has been shown to be harmless or helpful to patients/animals with renal disease (citation needed).

Rapamycin also had no effect on pruritis which was a symptom of food allergies. It’s possible it made matters worse, but such things are very difficult to establish. The dog had an enormous hot spot just prior to treatment and such hot spots occurred on 3 occasions after initiation of rapamycin treatment and he attacked them with even greater ferocity. Due to the dermatits, the dog was given benadryl for a few days prior to the blood test. It is unclear if the diphnhydramine could have cause nephrotoxicity. Both drugs have been implicated in renal damage.

Does Rapamycin have an anti-aging effect in dogs? Perhaps, but any such rejuvenation might be cancelled out by the symptoms of renal disease in this case. A few people have remarked that the dog seems younger. His energy level has been good. His mobility and arthritis symptoms seem improved.

It’s possible one chronic condition has improved as a result of the Rapamycin. I will have a better understanding of this potential when the dog has been free of rapamycin for a few weeks/months.

REFERENCES:
(1) Tomlanovich SJ, Vincenti F. Sirolimus: defining nephrotoxicity in the renal transplant recipient. Clin J Am Soc Nephrol. 2007 Mar; 2(2):198-9. PMID: 17699406.
(2) Marti, H.-P. and Frey, F.J. Nephrotoxicity of rapamycin: An emerging problem in clinical medicine. Nephrol Dial Transplant. 2005; 20: 13–15.

Rapid Improvement of Nailbed Infection in a Feline (pemphigus foliacious)

Dometic Shorthair Feline with persistent nailbed infection presented with multiple affected nailbeds. All nailbeds were affected, some were quite inflamed and infected with staph.

Oral use of colloidal silver for 3 weeks did not resolve the issue. Patient was routinely receiving 4 drops of DMSO daily orally to improve health of the stomach after an IBD diagnosis. Elizabethan collar for 2 hours to prevent immediate removal of the EVCO. Improvement was drastic and maintained with only twice weekly treatment. When my own illness prevented me from continuing the treatment, two of the beds became infected again but the cat is much more comfortable and will scratch her scratch pad and use her claws to knead and to grasp at string toys. I hope to resume treatment and to have assistance from one of my volunteers so that I might get some before and after photos to share here.

If you try DMSO, Colloidal Silver, and or Extra Virgin Coconut Oil on a pemphigus rash, please comment with your results.

Colloidal Silver Saves Pets Lives…

Colloidal Silver Saves Pets Lives…

… That’s my take, anyway. I am not a doctor, a veterinarianm or a person with an advanced education (unless you consider life experience to be educational). I do have an AS degree in animal health, but still am not speaking as an expert, as I was never taught about this in school. I am speaking as a hobby researcher who has seen and tested the benefits of colloidal silver on hundreds of occasions. You don’t have to take my word for it, just try it yourself. Just be sure to take your pet to a vet before and during treatment to ensure health is improving and not declining. Nothing works 100% of the time and I am not a vet, so do not rely on my information alone to try to save a pet’s life, please.

Instead of bringing home parvo virus, imagine bringing home healthy pups from the shelter. Instead of sad kittens with distemper, imagine bringing home healthy, robust kittens and them staying that way until you place them. Imagine no more kennel cough or instead of it lasting weeks, just days. This can be a reality with a few easy steps.

Having spent decades involved in animal rescue, I have learned a thing or two. One thing I picked up about 10 years ago was that Colloidal Silver is an invaluable antibiotic, anti-viral agent which may aso clear fungal infections. Nobody could argue the germ-killing ability of silver- it is now used in many medical products (ointments, bandages, eye drops) and day to day items which tend to get dirty (socks, shoes, fabrics..). Still, many people don’t know it can be use internally with a high margin of safety if it is a true colloid (do not believe everything you read). I have seen so many healing “miracles”, that I would never doubt it’s antiviral and antibacterial effect. As for it’s effect on fungus, I am not yet sold, fungus is tough to penetrate and erradicate so I believe it could help reduce fungal loads, but may not cure fungal infections (if you know otherwise, please comment!).

I recommend all pet rescuers learn about colloidal silver. Colloidal silver is a specific type of silver solution with very small particles which remain suspended in water. It usually contains silver ions (a single charged atom), but primarily it has very small particles which may have 2 or more silver atoms attached to one another.  An ideal colloidal silver has a particle small enough to enter the blood stream and not collect in tissues in a harmful way.

Ionic silver ais also known as silver hydrosol. It is often confused with colloidal silver or is mislabeled colloidal silver. Ionic silver can have the same effect in some applications but it is harder to get it into the bloodstream because it combines with chloride in the stomach. For best effect it must be given on an empty stomach. Often a solution will have particles as well as ions in which case I am not sure who gets to decide if it is a colloid or a hydrosol solution. In any case, there is no need to complicate your life with learning the difference, and the particle sizez, simply choose a product that is backed by a safety guarantee. I highly recommend MesoSilver as they guarantee it is non detrimental and you cannot overdose. I have seen the most dramatic improvements with this brand and it is reported to be a true colloid (so it gets into the blood easily and works systemically). It works when added to food or water or given directly by mouth. It also works topically but like all silver solutions, it may not penetrate deeply. If there is something like an abscess, you will want to flush it. If there is a deep tissue infection, cellulitis, or abscess, ask your vet if it is OK to add small amount of DMSO to help the silver penetrate. It makes sense to use them together to get the germ killing and anti-inflammatory properties of DMSO and the germ killing and pain relieving effects of silver.

Silver ions (not particles, according to my sources) will bind with chloride (from hydrochloric acid) in a stomach which is actively digesting. It is claimed they cannot kill germs once they turn into silver chloride, but I have seen good results offering ionic silver with small amounts of food, so I believe it still is effective, but not as effective as MesoSilver, the brand I trust most at this time. I find being able to add colloidal silver to the pet’s food is the easiest way to get it into them (if they are eating) and so I appreciate the MesoSilver colloid very much. I find I need much less of this brand than I do of any other brand  I have experimented with. That being said, if you can give a solution on an empty stomach (by syringe or in a water dish), the usuallymore affordable and easy to make at home ionic silver solution will often work just fine. Colloidalsilverguy.com sells the most affordable colloidal silver generator which I think is $20 with silver wire included.

Step number one in preventing disease in your rescue, is going to be, get the shelter/hoarder/puppy-mill/ and stray pets on colloidal silver as soon as possible. If you can encourage your shelter to put colloidal silver in the food/water of the pets they house, this may very much reduce the time you need to quarantine new pets. If shelters got on board and offered this to all pets, I believe kennel cough, distemper, and parvo would be non-existent unless a pet came in with it and then, the chance of pets nearby contracting it, would be much less. It would proably cost from one to fifty cents per day per pet to protect pets in a shelter, so it isn’t an impossible dream.  Colloidal silver is safe for pregnant animals from what I have read, and should not interfere with other therapies. There are even non-toxic ionic-silver, surface sprays which can be used on kennels, beds, walls, clothing, and anywhere else germs would be. Pure Bioscience makes a non toxic silver and citric acid solution which is more effective than any common kennel disinfectant and it won’t harm the respiratory tract or otherwise harm pets. I don’t know you’ve ever used a kennel sanitizer, but they usually make me want to cough so I am sure they are contributing to respiratory distress and infections in dogs and cats.

For the sake of experimentation, consider giving kittens colloidal silver twice per day  at the very first sign of URI. If you use the right silver solution, you may find that the URI never becomes a full blown illness Now, if you want to be more scientific, offer the silver to only half of the kittens for a couple of days. If you don’t see that the treated kittens are doing better than the untreated, I would question the quality of the silver you’re using. Keep in mind, once mucus forms and sinuses are congested, it will be more difficult to rid the kitten of the pathogen as it can get trapped in the mucus and continue to reinfect the tissues. There is no great way to get silver to ooze out of the tissues into an infected pocket, but if the animal is well-infused with silver ions or particles, infection of tissue cannot occur so be persistent and treat abscesses, cellulitis, pleuritis, cancer, and other substantial infections for as many days and weeks are needed for the body to transport the dead cells away. I have seen kittens stop sneezing in a matter of hours with just a few drops of colloidal silver. I have seen kittens start sneezing again a day or two after the silver was discontinued and recover again within hours of a dose. This is something you might see when you catch a URI early, before mucus sets in . Once mucus sets in, it will take days to see improvement.

For dogs with kennel cough, I like to put drops (1 drop per 10lbs of dog) of colloidal silver in each nostril. If you don’t want to upset the dog, buffer the solution with a bit of salt but then you are adding chloride and potentially reducing the effectiveness of the silver so use a colloid  and not an ionic solution for best results. A nebulizer can also do the trick to get silver ions and nanparticles into the sinuses. A nebulizer should never be used without your vet’s approval or without paying extreme amounts of attention to how the pet reacts. Some will find the process irritating and if it’s not a URI but a full blown bronchitis or pneumonia, you may see fits of coughing or even breathlessness. Silver can be irritating to the lungs in some cases so please consult your vet when dealing with any mid-lower respiratory tract infection or other serious illness.

Silver can work wonders for a UTI as well. If you have a feline with FLUTD, or a dog with chronic UTI, you may find colloidal or ionic silver in the water bowl takes care of the infection and/or pain. If you have an intact female dog, offering colloidal silver for the second half of the heat and the following 2-3 weeks is recommended (by me) to prevent pyometra. For preventing pyometra, I use a fairly hefty dose for the final 2 weeks of the heat and the following 2 weeks then lighten up to a maintenance dose for the two weeks after.  If the dog were older or otherwise more at risk, I would offer a hefty dose for the entire heat and 4 weeks post heat and a moderate dose for life. I do not get concerned about killing of colon bacteria as the silver should be absorbed into the body or inactivated before it reaches the colon (if there is diarrhea, this may not be the case, so play by ear). For any dog experiencing pyometra, if surgery is not an option I would administer colloidal silver at a high dose orally, assuming my vet has not advised against it. I would also use DMSO plus colloidal silver (50/50) applied to the bare (shave if necessary) skin over the ventral abdomen (entire belly) and inner thighs so that the solution is covering roughly 20% of the dog’s total skin area  every few hours with my vet’s approval (DMSO can be irritating). DMSO is a pain reducer, anti-infective, anti-inflammatory, and in my opinion, an all-around miracle worker when it comes to healing anything stubborn. In humans is is infused into the bladder to treat interstitial cystitis (basically inflammation and or infection within the bladder lining- a condition which is resistant to antibiotics). I’d be inclined to try a solution of 10-30% DMSO in colloidal silver instilled into the uterus in small amounts (perhaps 1ml/kg). I’d be careful adding any volume to a significantly distended uterus or closed pyometra. I wouldn’t want to risk overdose or rupturing a delicate uterine wall. If i had the ability to use intra-uterine catheter and endoscopy, I’d feel comfortable trying this in a stable, non-febrile patient.  A uterus would not likely drain as rapidly or completely as a bladder would so I would hesitate to use the 50% strength found in Rimso-50(R), the DMSO solution approved to treat interstitial cystitis.

I also use DMSO and colloidal silver (or gold) treatment for cats with squamous cell carcinoma of the mouth (applying only outside the mouth if cat objects to flavor) or other cancers which are not operable. The DMSO and silver can penetrate quite deeply to provide pain relief and control of inflammation without the harsh effects of a steroid such as prednisone (this does not mean you should not use prednisone- it has the ability to reduce tumor growth). Personally I woult not feel comfortable stoppin prednisone if it can prolong life, but I would consider using less and using DMSO with colloidal silver applied dermally.

I am not a veterinary or medical professional. I do not diagnose, treat, or claim to prevent or cure disease. I simply read a lot, experiment a lot, and encourage others to experiment safely and with the supervision of professionals. I have a background in veterinary technology, and unless you have this, I would stick to using silver as a preventive agent. Only use it to treat illness under the guidance of veterinarian.

Now go save some pets!

 

Sage Advice on Chronic Disease

 

sage puppy rita pink

My intent is not to frighten people, but to empower those who find themselves in need of assistance. If your pet does not have chronic illness, reading further about this, will only serve to create negativity and fear and is not recommended.

As a person who’s seen dozens of animals obtain wellness on a raw diet, I have to sing the praises of natural nutrition. By “natural” I do not simply mean unprocessed, I mean what nature intended. I’ve seen animals go from a pathetic state where they needed steroids to survive a flea bite, to not needing any flea preventive or medication of any type. I’ve read about heartworm cases that clear up on their own (without the animal becoming very ill), when the only support was nutritional.

Oftentimes, when we take away natural, we leave gaps in nutrition which results in “holes” in the animal’s health. Some holes are seemingly “filled” with medication and other vet care, but this solution is often an illusion. No pet should need steroids, antibiotics, medicated shampoos, or pesticides, if it is healthy. Even torn ligaments, and hip dysplasia can be preventable with nutrition and holistic management (1). While we pretend to fill holes with medications and expensive prescription diets, they may just get deeper.

In modern America, it seems uncommon to know a dog or cat over the age of 10 years who doesn’t need regular veterinary care… that’s if they make it to 10. As a child and teenager, I remember having outdoor (hunting) cats who lived into their 20’s. They never saw a vet except in their first year of life when they were spayed or neutered. These cats were typically vaccinated once or twice as kittens and that was it. And that leads me to my next biggest pet peeve after inferior nutrition- the carelesss use of vaccines.

Vaccinosis is a term used to describe a broad range of side effects caused by vaccines which we are told are “safe”. Vaccinosis may include diseases such as allergies, renal failure, epilepsy, diabetes, and cancer. The uncommon, severe, immediate and sometimes deadly vaccine reactions are nothing compared to the cummulative suffering of pets who develop chronic illness from vaccines. Don’t expect your regular vet to be aware of these as it isn’t typivally discussed in veterinary school.

If you are dealing with one or more of these symptoms please research vaccinosis and holistic treatments. If you need help choosing a treatment, we would be happy to answer a couple questions at no charge. If you need further assistance, we can offer a wellness consultation. Just remember that autoimmune diseases almost always (what I have found, not a medical fact) involve inflammatory processes and certain diets can reduce inflammation (this is a medical fact).

The pet who opened my eyes to chronic vaccinosis and the results of inadequate nutrition was Sage, a foster puppy from Mexico. Aside from being a little skinny, Sage seemed healthy while living on the streets for her first 4 1/2 months of life (photo above). When she was rescued and vaccinated, her health declined to a pathetic state. My vet blamed vaccines. It was the first time I’d heard of a delayed or chronic vaccine reaction even though I had graduated from a two year veterinary technology program. I was “educated” on vaccines in much the same way most vets are, so I understand why they don’t get it.

Sage’s struggle opened my eyes to the immunosuppression and autoimmune disorders, linked to vaccination. Not surprisingly, these are the leading causes of illness in pets today. Combined with nutritional inadequacy, these often make for a disaster. Before you get on me for being negative and fear mongering, know that I have spent 15 years researching this subject extensively. There is a huge amount of evidence linking vaccines to cancers and autoimmune conditions. And lest you say this is “negative”, let me say that I think this is good news. After all, it’s easy to avoid over-vaccinating and it’s often easy to manage vaccinosis with nutrition.

A few weeks after vaccination, Sage displayed many symptoms of a weakened immune system. She had been adopted out but was returned three weeks later with a terrible case of sarcoptic mange. It’s likely the mange mites were lving in non-harmful numbers on her while she lived on the streets. Her immune system was likely strong enough to keep the infection under control despite her diet of trash, and scraps. Once she was vaccinated, that changed. Sage not only developed a mite infestation but she also developed hundreds of warts around and in her mouth. Another dog, Juniper, used to lick the inside of Sage’s mouth to try to sooth the infection and perhaps to try to share some of her immunity. Neither Juniper, nor the other dogs in my care, ever caught the communicable mites or warts indicating further that Sage had an extremely compromised inmmunse system. The other dogs, weren’t on any special diets or particularly healthy, but they were far healthier than the youngster. The sarcoptic mange was treated aggressively with toxic medications and eventually “cured”. The relief of that news lasted less than 5 minutes.

The day she received her first negative skin scraping for sarcoptic mange, Sage received a new diagnosis- Demodectic mange. It was showing as a small spot on her front leg, so we were hopeful we could cure it with medication. Despite aggressive treatment, Sage developed generalized (covered most of her body), demodectic mange with secondary bacterial infections that antibiotics could not control. Sage lived the majority of her puppyhood (age 6 months to 14 months) with fever, swollen glands, and oozing sores on half of her body.

The good news was that this mange wasn’t contagious and her warts had proven to not be contagious to the many dogs I had fostered, so I was able to take her to the dog park. Sadly, most people wouldn’t let their dogs near the half-bald puppy and I didn’t blame them. I kept her on leash with me away from other dogs until we saw a familiar friend who was allowed to play with her. When she did have a playmate, her delicate skin bled from the dog mouthing or pouncing on her. She didn’t mind, she just wanted to play.

I struggled with the idea of making her live like that but didn’t have the hear to put her to sleep. She was the smartest dog I had ever known. She was freakishly intuitive and would stare in your eyes like she was reading your every thought. When I thought about putting her down, she would bring me a ball and bark at me to play fetch with her, or do something equally demonstrative of her enjoyment of life and seeming will to live. Still, after several months of this, I thought the only fair thing would be to put her down.

With a heavy heart, I gave Sage to another rescue that dealt with dogs from Baja Mexico. I asked the kind foster mom, Katie, to keep Sage for one month with the agreement that if Sage improved, Katie would rehome her. If Sage didn’t improve, Katie agreed to have a vet end the suffering. I was so sad leaving Sage in this situation, but I needed that month to clear my head and get another person’s perspective on Sage’s quality of life. Katie tried to keep an emotional distance from Sage by keeping her strictly outdoors (with a doggy friend, and cozy dog house). When it was time, she couldn’t go through with the euthanasia. She told me Sage was incredibly intelligent and it would be a shame to give up on a dog like her. I knew sage was unusually perceptive and extremely focused on her people. This was the trait I kept highlighting to justify pouring all of my time and money into one quite pathetic looking, struggling, pet as I passed up the opportunity to help many others. I knew as much as my life did not have room for this dog, I had to keep helping her. Little did I know she would completely change the way I viewed health.

The prescribed medications kept her alive but she was not well. I had to find a cure. I tried everything I could think of including the unthinkable- raw chicken. Can you imagine feeding raw chicken to someone with a weak immune system? It seemed like a very bad idea at the time, but I was desperate and had read one testimony on the internet that this worked to cure demodex in one dog. I swallowed my vegetarian pride and fears about handling raw meat and brought slimy raw chicken into my home and fridge (ewww).

sage(blakFace)PacoYard

 

To my surprise, the diet changed worked almost imediately. In less than two weeks, Sage’s wounds had healed, her lymph nodes shrank and her fever was gone. In three weeks, she was cured from demodectic mange and the warts that filled her mouth. The photo above shows sage about three weeks into the raw chicken diet. Her skin was healed (Albeit very tanned) and her fur was growing back. In no time, all of her fur returned and she was a beautiful dog.

Each time I tried to wean Sage onto a kibble diet, no matter how “nutritious” or holistic the kibble was, or how closely it resembled the raw diet I was feeding her she relapsed. And, again, a few weeks of a strictly raw diet remedied the illness. I was excited about the new knowledge but as a vegetarian I was eager to get rid of the dog who required me to stock my fridge with raw meat and threatened to eat my cats.

 

On my relationship with Sage-

I tried to rehome Sage for many years without much luck. She was a very high drive, energetic dog who needed to be working. She was never going to be a dog who was content with two walks a day, she needed hours of outdoor running and then lots of indoor playing with other animals, that’s just the way she was built. She was happy to be a full time service dog and could perform tasks with precision, but she needed to play too. She played more than any dog I had ever met in my life and I’ve met a lot of dogs. If I refused to play fetch with her, she would wear out her 4-legged housemates one-after-the-other and then go play a game of fetch with herself. She was vivacious, to say the least.

One day, someone shared the notion  “You don’t choose your dog, your dog chooses you”. A tear came to my eye as I realized I had no say in the type of dog I was going to own. I was already owned. I finally gave up on finding Sage a new home. I wish I’d done that sooner. She deserved to be loved fully and for years she was respected and cared for, but not fully loved. That’s one more thing she taught me- to love with all of my heart, regardless of a pet’s temporary status in my life. You never know when a foster pet is really meant to be yours. You may keep your distance for months or years for the sake of sparing a broken heart when you rehome a pet. The broken heartedness you feel when you realize you’ve missed out, isn’t worth it. (Thank you, Sage, for teaching me this.)

 

sage max blog

It took me a decade to figure out what Sage new from the moment we met on the sidewalk in Rosarito Beach, Mexico. She ran up to me, climbed up my body as I kneeled, and licked my face as if to say “You are the one!”. She stuck to me like glue and ignored every other person on the sidewalk. She was a wise creature, even at that young age. Sage’s story, my story, shows us that fighting fate is pointless and maybe the the things that seem backwards or wrong are really the answer to our problems. Who’d have thunk.

Sage side yard

Dear Sage- I would say “Rest in Peace”, but I you’re probably running marathons on endless beaches in doggy heaven and loving it. Don’t rest, run like the wind, my sweet girl. When you are ready to come back to me, run right into me like you did when I found you (or vice versa?) on the street. I promise not to turn away from you again. The ache I feel in my heart is not due to your physical absence, but do to my emotional absence when you were physical. I would like a do-over.

XXOO, Mommy